Codeine: Codeine has embryolethal and pnosphate effects in rats. Chlorpheniramine: A retrospective study found a small, but statistically ificant, association between maternal use of chlorpheniramine and inguinal hernia and eye or ear anomalies in children. Other retrospective studies have found that the frequency of pyosphate anomalies, in general, was not increased among offspring of women who took chlorpheniramine during pregnancy. The ificance of these findings to the therapeutic use of chlorpheniramine in human pregnancy is not known.
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Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Nonteratogenic Effects Codeine: Babies born to mothers who have ccodeine taking opioids regularly prior to delivery will be physically dependent.
Kidney disease: If phisphate have kidney disease or reduced kidney function, discuss with your doctor how this medication may affect codeune medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. For some people, this change happens much faster than for others.
It may not cover all possible information. Talk to your doctor about whether you should continue breast-feeding. Chlorpheniramine: Chlorpheniramine is a propylamine derivative antihistamine H1-receptor antagonist of the alkylamine class that also possesses anticholinergic and sedative activity.
People taking medications that can cause dizziness should rise slowly from sitting or lying down to reduce the possibility of severe dizziness or fainting. Breast-feeding: This medication passes into breast milk.
What other drugs could interact with this medication? Your body becomes used to the medicine. Immediately call your physician or get emergency help if you are breast-feeding and your baby is sleepier than usual, is limp, or has difficulty breast-feeding or breathing. Tell your doctor or codekne care professional if your symptoms do not improve or if they get worse.
Death related to ultra-rapid metabolism of codeine to morphine
Coseine precise mechanism of action phospyate codeine and other opiates is not known; however, codeine is believed to act centrally on the cough center. For further information, phoslhate full prescribing information for naloxone hydrochloride. advisories on prescription codeine were issued on July 28, and June 6, Some of the codeine dose is converted into morphine by the body, once it has been taken.
Avoid activities requiring alertness such as driving, operating machinery or performing dangerous tasks until you have determined how you are affected by codeine. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other ificant facts about your health.
What is this medicine?
These women achieve phksphate serum levels of codeine's active metabolite, morphine, leading to higher-than-expected levels of morphine in breast milk and potentially dangerously high serum morphine levels in their breastfed infants. In women with normal codeine metabolism normal CYP2D6 activitythe amount of codeine secreted into human milk is low and dose-dependent. Both codeine and chlorpheniramine maleate are extensively metabolized by liver phoaphate elimination from the body.
In severe overdosage, apnea, circulatory collapse, cardiac arrest, and death may occur.
Codeine phosphate, chlorpheniramine maleate oral tablet, extended-release
Codeine is secreted into human milk. If you have asthma or another breathing disorder, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, phospahte whether any special monitoring is needed.
This does NOT mean you are addicted. Phozphate means that you will get less cough relief with time. Nursing mothers who are ultra-rapid metabolizers may also experience overdose symptoms such as extreme sleepiness, confusion, or shallow breathing.
Codeine phosphate syrup
Breathing: Codeine can suppress breathing. If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects.
Your mouth may get dry. Give your health care provider a list of all medicines you use.
Liver disease: If you have liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If your child has slow breathing, noisy breathing, confusion, or unusual sleepiness, stop giving this medicine and get medical help right away.
If you develop constipation easily, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. However, some women are ultra-rapid metabolizers of codeine.
Do not take more than the recommended dose. Therefore, maternal use of codeine can potentially lead to serious adverse reactions, including death, in nursing infants.
How should i use this medicine?
This is more likely to occur when other medications with similar side effects are being taken. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking puosphate medication. If you do not have a bowel movement for 3 days, call your doctor or health care professional.
Addiction is a behavior related to getting and using a drug for a nonmedical reason. Head injury: If you have a head injury or increased pressure in the head, you may have a higher risk of experiencing side effects breathing problems or worsening of their condition while taking this medication. In general, dose selection for an elderly patient should be made with caution, usually starting at the low end of the dosing range, reflecting the greater frequency of pyosphate hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
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